Week 6 of the 2024 NFL regular season is on the immediate horizon, and it's the second in a row with a London Series contest. The Jacksonville Jaguars begin their annual 2-week trek in their home away from home across the pond, kicking off Sunday's slate against the Chicago Bears. That is preceded by Thursday Night Football, which features the San Francisco 49ers and Seattle Seahawks adding a chapter to their NFC West rivalry. Both New York teams are a lso featured in primetime slots, with the Giants facing the Cincinnati Bengals and the Jets running into the AFC East rival Buffalo Bills.'
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 6'opening lines and give our best early bet to make.
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NFL Week 6 opening lines and odds'
Odds available at DraftKings Sportsbook at time of publishing'