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With a schedule full of Big Ten and SEC matchups, we're making our Week 6 college football expert picks.
- Oregon looks to reignite its college football championship odds against a struggling Michigan State program
- A College Football Playoff odds contender, Missouri has a chance at its first quality win of the season against a surging Texas A&M team
- Despite his Heisman Trophy odds taking a hit last week, Ole Miss QB Jaxson Dart can get back on track against South Carolina
As part of our Week 6 college football predictions, our experts break down their top picks for the best games this weekend. Shane Jackson continues offering up his best bets with his college football Week 6 player prop picks.
Mike Spector also offers his Week 6 college football predictions & best bets Week 6, which focus in on some of the less heralded matchups on the board.
College football expert picks for Week 6
College football odds as of Thursday and subject to change. See all of our college football picks for more on this week's top matchups.
| Rob Paul | C Jackson Cowart | |
|---|---|---|
| Michigan State vs. Oregon | Aidan Chiles 2+ interceptions (+230 via bet365) | Oregon -23.5 (-110 via BetMGM) |
| Missouri vs. Texas A&M | Luther Burden Over 69.5 receiving yards (-115 via Caesars) | Missouri +2.5 (-110 via DraftKings) |
| Iowa vs. Ohio State | Will Howard Under 247.5 passing yards (-114 via FanDuel) | Under 45.5 (-110 via BetMGM) |
| Auburn vs. Georgia | Trevor Etienne Over 85.5 rushing yards (-109 via Caesars) | Georgia -22 (-112 via DraftKings) |
| Ole Miss vs. South Carolina | Tre Harris Over 93.5 receiving yards (-115 via bet365) | Under 53.5 (-105 via BetMGM) |
| Clemson vs. Florida State | Phil Mafah Over 85.5 rushing yards (-114 via FanDuel) | Clemson -14.5 (-102 via FanDuel) |
Top picks for Week 6
Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
The Spartans offense is one of the worst in the country – 111th in SP+ – and Chiles is a large reason why. He's thrown 2-plus interceptions in three of five games and is second in the country in both interceptions (8) and turnover-worthy plays (14), per PFF.
Meanwhile, Oregon's defense is eighth in EPA per dropback and has one of the most talented secondaries in the country. If the Ducks can pick Chiles off twice, a $10 bet pays a $23 profit.
The Ducks defense is a key reason why Mike Spector likes the home team in his Michigan State vs. Oregon prediction.
Best odds: +230 via bet365 | Implied probability: 30.30%
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