The No. 22 Louisville Cardinals (3-1, 0-0 ACC) welcome the SMU Mustangs (4-1, 1-0) to L&N Federal Credit Union Stadium Saturday. Kickoff is set for noon ET (ESPN). Let’s analyze BetMGM Sportsbook’s college football odds around the SMU vs. Louisville odds, and make our expert college football picks and predictions.
Louisville is No. 22 in the . The Cardinals beat Austin Peay 62-0 to kick off the season and won each of their first 3 games by 12 or more points. Louisville lost its lone competitive game of the season 31-24 to the No. 13 Notre Dame Fighting Irish in Week 5, closing as a 6.5-point underdog.
SMU beat the Florida State Seminoles 41-26 in Week 5, covering as a 6-point home favorite. The Mustangs have rallied off 2 straight wins, scoring a total of 108 points in the victories. Their lone loss of the season was an 18-15 home defeat to No. 19 BYU, failing to cover as a 12.5-point favorite. SMU is 3-2 ATS on the season and 1-0 ATS in conference play.
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