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After the biggest week of the college football season so far, our college football Week 6 predictions feature just one ranked matchup but a whole host of tricky conference matchups for top teams.
The action begins Thursday with the first marquee game coming Friday when Michigan State travels to face Oregon for a 9 p.m. ET kickoff from Autzen Stadium. Phil Wood broke that matchup down in his Michigan State vs. Oregon early picks.
The top game on Saturday kicks off at noon ET when Missouri faces Texas A&M in a matchup between college football championship odds contenders from the SEC.
Later in the day, Michigan faces Washington rematch of last year's title game as the Wolverines look to keep their College Football Playoff odds alive for another week. That contest kicks off at 7:30 p.m. ET on NBC.
Saturday's action wraps with H eisman Trophy odds contender Cam Ward and eighth-ranked Miami traveling to face California at 10:30 p.m. ET in their first clash as ACC foes.
College football picks & predictions Week 6
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- Texas State vs. Troy prediction
- Sam Houston vs. UTEP prediction
- Jacksonville State vs. Kennesaw State prediction
- Houston vs. TCU prediction
- Syracuse vs. UNLV prediction
- Michigan State vs. Oregon early picks
- Michigan State vs. Oregon prediction
- Michigan State vs. Oregon player props
- Navy vs. Air Force early picks
- Navy vs. Air Force prediction
- Navy vs. Air Force player props
- Missouri vs. Texas A&M prediction
- Auburn vs. Georgia prediction
- Iowa vs. Ohio State player pro ps
- Michigan vs. Washington
- Miami vs. California prediction
- Miami vs. California player props
Don't miss the rest of our Week 6 college football picks.
College football odds for Thursday
College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.
- When: Thursday, Oct. 3 – 7 p.m. ET
- Where: Veterans Memorial Stadium, Troy, Ala.
- How to watch: ESPNU
- Moneyline: Texas State -575 | Troy +425
- Spread: Texas State -14 (-112) | Troy +14 (-108)
- Total: 57.5 (-110/-110)
- When: Thursday, Oct. 3 – 9 p.m. ET
- Where: Sun Bowl, El Paso, Texas
- How to watch: CBSSN
- Moneyline: Sam Houston -395 | UTEP +310
- Spread: Sam Houston -10 .5 (-108) | UTEP +10.5 (-112)
- Total: 50 (-110/-110)
College football odds for Friday
- When: Friday, Oct. 4 – 7 p.m. ET
- Where: Fifth Third Stadium, Kennesaw, Ga.
- How to watch: CBSSN
- Moneyline: Jacksonville State -700 | Kennesaw State +500
- Spread: Jacksonville State -14.5 (-110) | Kennesaw State +14.5 (-110)
- Total: 48.5 (-112/-108)
- When: Friday, Oct. 4 (7:30 p.m. ET)
- Where: Amon G. Carter Stadium, Fort Worth, Texas
- How to watch: ESPN
- Moneyline: Houston +525 | TCU -750
- Spread: Houston +16 (-108) | TCU -16 (-112)
- Total: 49.5 (-110/-110)
- When: Friday, Oct. 4 (9 p.m. ET)
- Where: Autzen Stadium (Eugene, Ore.)
- How to watch: FOX
- Moneyline: Michigan State +1100 | Oregon -2100
- Sprea d: Michiga State +24 (-110) | Oregon -24 (-110)
- Total: 52 (-112/-108)
- When: Friday, Oct. 4 (9 p.m. ET)
- Where: Allegiant Stadium, Las Vegas
- How to watch: FS1
- Moneyline: Syracuse +190 | UNLV -230
- Spread: Syracuse +6 (-110) | UNLV -6 (-110)
- Total: 59.5 (-108/-112)
College football odds for Saturday
- When: Saturday, Oct. 5 (noon ET)
- Where: Falcon Stadium (U.S. Air Force Academy, Colo.)
- How to watch: CBS
- Moneyline: Navy -380 | Air Force +300
- Spread: Navy -9.5 (-115) | Air Force +9.5 (-105)
- Total: 34.5 (-108/-112)
- When: Saturday, Oct. 5 (noon ET)
- Where: Kyle Field (College Station, Texas)
- How to watch: ABC
- Moneyline: Missouri +110 | Texas A&M -130
- Spread: Missouri + 2 (-108) | Texas A&M -2 (-112)
- Total: 48.5 (-110/-110)
- When: Saturday, Oct. 5 (7:30 p.m. ET)
- Where: Alaska Airlines Field at Husky Stadium (Seattle)
- How to watch: NBC
- Moneyline: Michigan +115 | Washington -140
- Spread: Michigan +2.5 (-105) | Washington -2.5 (-115)
- Total: 40.5 (-110/-110)
- When: Saturday, Oct. 5 (10:30 p.m. ET)
- Where: California Memorial Stadium (Berkeley, Calif.)
- How to watch: ESPN
- Moneyline: Miami -375 | California +295
- Spread: Miami -10 (-112) | California +10 (-108)
- Total: 54.5 (-112/-108)
College football picks roundup: Week 6
- College football against the spread picks Week 6
- College football upset picks Week 6
- College football expert picks Week 6
- College football predictions & best bets Week 6
- College football player props Week 6
- Big Ten predictions
- SEC predictions
- Big 12 predictions
College football betting odds pages
| College football championship odds | College football win totals | Big Ten championship odds | Mountain West championship odds |
| Heisman Trophy Odds | FCS Championship odds | Big 12 championship odds | MAC championship odds |
| College Football Playoff Odds | SEC championship odds | ACC championship odds | College bowl game odds |
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