Astros vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Sep. 27
Astros vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Sep. 27

The Houston Astros (+105) visit Progressive Field to take on the Cleveland Guardians (-125) on Friday, September 27, 2024. First pitch is scheduled for 7:10pm EDT in Cleveland, OH.

This season, the Astros are 86-73 against the spread (ATS), while the Guardians are 82-77 ATS.

Astros vs Guardians Starting Pitchers Today:

  • Astros starting pitcher: Ronel Blanco 12-6, 2.89 ERA
  • Guardians starting pitcher: Joey Cantillo 2-3, 4.77 ERA

Astros vs. Guardians Odds, Run Line, Over/Under & Moneyline

Astros vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Friday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Astros players for Friday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

  • Jeremy Pena has hit the Home Runs Over in 5 of his last 19 away games (+23.40 Units / 123% ROI)
  • Yainer Diaz has hit the Hits Over in 23 of his last 46 games (+10.90 Units / 19% ROI)
  • Yainer Diaz has hit the RBIs Under in 14 of his last 16 games (+10.45 Units / 32% ROI)
  • Alex Bregman has hit the Total Bases Over in 16 of his last 25 away games (+9.70 Units / 37% ROI)
  • Jason Heyward has hit the Singles Over in 9 of his last 13 away games (+9.15 Units / 70% ROI)

And here are some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Lane Thomas has hit the Home Runs Over in 7 of his last 20 games (+24.60 Units / 123% ROI)
  • Jose Ramirez has hit the Hits Over in 16 of his last 19 games at home (+10.05 Units / 23% ROI)
  • Lane Thomas has hit the Runs Under in 18 of his last 24 games at home (+9.80 Units / 26% ROI)
  • Jose Ramirez has hit the RBIs Under in 21 of his last 27 games (+9.60 Units / 20% ROI)
  • Lane Thomas has hit the Total Bases Under in 17 of his last 24 games at home (+9.05 Units / 26% ROI)
  • The Houston Astros have hit the Game Total Under in 45 of their last 70 away games (+18.50 Units / 24% ROI)
  • The Houston Astros have covered the Run Line in 56 of their last 101 games (+13.15 Units / 11% ROI)
  • The Houston Astros have covered the 1st Five Innings (F5) Run Line in 17 of their last 24 away games (+9.40 Units / 33% ROI)
  • The Houston Astros have hit the Moneyline in 53 of their last 86 games (+9.05 Units / 7% ROI)
  • The Houston Astros have hit the Team Total Over in 69 of their last 123 games (+8.25 Units / 6% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 41 of their last 67 games (+16.70 Units / 23% ROI)
  • The Cleveland Guardians have hit the Moneyline in 92 of their last 159 games (+13.45 Units / 7% ROI)
  • The Cleveland Guardians have covered the Run Line in 38 of their last 74 games at home (+13.30 Units / 16% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 12 games (+8.15 Units / 52% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 4 of their last 5 games (+3.10 Units / 50% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 79-80 against the Run Line (+0.4 Units / 0.21% ROI).

  • 86-73 when betting on the Moneyline for -10.95 Units / -4.67% ROI
  • 65-89 when betting on the total runs Over for -32.25 Units / -18.55% ROI
  • 89-65 when betting on the total runs Under for +17 Units / 9.65% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 82-77 against the Run Line (+7.9 Units / 3.95% ROI).

  • 92-67 when betting on the Moneyline for +13.45 Units / 6.51% ROI
  • 69-80 when betting on the total runs Over for -19.25 Units / -10.97% ROI
  • 80-69 when betting on the total runs Under for +4.05 Units / 2.32% ROI

Guardians vs Astros Home Run Prop Bets Today

Over Under

Kyle Tucker (HOU)
0.5 +340 0.5 -450

Kyle Manzardo (CLE)
0.5 +400 0.5 -550

Jose Ramirez (CLE)
0.5 +400 0.5 -550

Josh Naylor (CLE)
0.5 +450 0.5 -650

Jose Altuve (HOU)
0.5 +500 0.5 -700

Guardians vs Astros Total Hits Prop Bets Today

Over Under

Steven Kwan (CLE)
0.5 -275 0.5 +195

Alex Bregman (HOU)
0.5 -250 0.5 +190

Kyle Tucker (HOU)
0.5 -250 0.5 +180

Jose Ramirez (CLE)
0.5 -250 0.5 +175

Victor Caratini (HOU)
0.5 -225 0.5 +165

Guardians vs Astros RBI Prop Bets Today

Over Under

Yainer Diaz (HOU)
0.5 +135 0.5 -175

Kyle Tucker (HOU)
0.5 +145 0.5 -200

Jose Ramirez (CLE)
0.5 +150 0.5 -200

Alex Bregman (HOU)
0.5 +155 0.5 -210

Josh Naylor (CLE)
0.5 +155 0.5 -210

Guardians vs Astros Strikeout Prop Bets Today

Over Under

Ronel Blanco (HOU)
4.5 -110 4.5 -120

Joey Cantillo (CLE)
4.5 +130 4.5 -165

Opponents have a miss rate of 37% (77/208) against Ronel Blanco on the first pitch of at-bats this season — best among qualified SPs in MLB; League Avg: 26% — 100th Percentile.

Ronel Blanco has walked 31 of 261 batters (12%) when going through the lineup the first time in a game this season — highest among qualified SPs in MLB; League Avg: 7% — first Percentile.

Ronel Blanco has walked 23 of 188 batters (12%) versus the bottom of the order this season — highest among qualified SPs in MLB; League Avg: 6% — first Percentile.

Ronel Blanco has walked 50 of 428 batters (12%) versus hitters not batting 3-4-5 in the order this season — highest among qualified SPs in MLB; League Avg: 6% — first Percentile.

Guardians Starting Pitcher Stats & Trends

Joey Cantillo has not allowed a home run in any of the last 19.2 innings he’s appeared — Cionel Perez has the longest active streak at 87.2.

Joey Cantillo has a strikeout rate of 37% (22 SO in 60 PAs) this month (3 games) — 4th best in MLB among starting pitchers with at least 8 total IP; League Avg: 23% — 98th Percentile.

Joey Cantillo has not allowed a HR in any of his last three starts dating back to September 9th — Beau Brieske has the longest active streak at 15.

Opponents have a miss rate of 36% (42/117) against Joey Cantillo this month (3 games) — 3rd best in MLB among starting pitchers with at least 8 total IP; League Avg: 26% — 98th Percentile.

Astros Keys to the Game vs. the Guardians

  
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