First look: Louisville at Notre Dame odds and lines
First look: Louisville at Notre Dame odds and lines

The No. 17 Louisville Cardinals (3-0) take on the No. 14 Notre Dame Fighting Irish (3-1) Saturday at Notre Dame Stadium. Kickoff for is set for 3:30 p.m. (Peacock). Below, we look at Louisville vs. Notre Dame odds from BetMGM Sportsbook’s college football odds before making our expert college football picks and predictions'later in the week.

Louisville prevailed 31-19 against Georgia Tech Saturday, covering as a 9.5-point home favorite. QB Tyler Shough was 13-for-19 for 269 yards with 2 TDs and 0 interceptions. The Cardinals only managed 57 yards on the ground on 27 rushes, but 2 defensive touchdowns were paramount.

Notre Dame took down the Miami (Ohio) RedHawks 28-3 last week. The Irish dropped to 2-2 against the spread (ATS) after failing to cover as 27-point home favorites. They are 0-2 ATS when favored by more than 7 points. RB Riley Leonard finished with 143 rushing yards with 2 TDs on 12 carries.

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