A relatively close victory is expected for the Arizona Cardinals (1-1) when they meet the Detroit Lions (1-1) on Sunday, Sept. 22 at State Farm Stadium (beginning at 4:25 p.m. ET). Our computer prediction projects the final score as 27-22.
Lions vs. Cardinals predictions
- Pick ATS: Cardinals (+3)
- Pick OU: Under (51.5)
- Prediction:
Cardinals 27 – Lions 22
Lions vs. Cardinals odds and lines
National Football League odds courtesy of BetMGM. Odds updated Saturday at 5:40 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread favorite: Lions (-3)
- Moneyline: Lions (-150), Cardinals (+125)
- Total: 51.5 points
Lions betting stats
- Detroit has one win against the spread this year.
- As a 3-point favorite or greater, the Lions have one win ATS (1-1) this season.
- None of Detroit’s two games has gone over the point total in 2024.
Cardinals betting stats
- Arizona has posted two wins against the spread this season.
- The Cardinals are yet to lose ATS (1-0) as a 3-point underdog or greater this season.
- Arizona and its opponent have yet to finish under the total this season.
- The Cardinals lost the only game they’ve played as the underdog this season.
Lions vs. Cardinals game info
- Game day: Sunday, September 22, 2024
- Game time: 4:25 p.m. ET
- TV channel: FOX
- Location: Glendale, Arizona
- Stadium: State Farm Stadium
- TV channel: FOX
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