Monday Night Football's first game of a doubleheader kicks off from Buffalo with the Bills battling the Jaguars.'
Buffalo is off to another strong start. They've started the season 2-0, including a 31-10 thumping of the Dolphins on Thursday night in Week 2.'
Jacksonville, meanwhile, has started 0-2 after losses to the Dolphins and the Browns. In good news, Jacksonville gets a Bills team they beat 25-20 in London last season.'
Here's a look at the NFL betting lines and my Bills vs. Jaguars prediction.'
Bills vs. Jaguars Odds
- Buffalo Bills Moneyline: -250
- Jacksonville Jaguars Moneyline: +200
- Game Spread: Buffalo Bills -5.5 (-110)
- Game Over/Under: 45.5 Points