The San Francisco 49ers (1-1-0) visit SoFi Stadium to take on the Los Angeles Rams (0-2-0) on Sep. 22. Kickoff is scheduled for 4:25pm EDT in Inglewood, CA.
The 49ers are betting favorites in this matchup, with the spread sitting at -7.5 (-105).
The 49ers vs. Rams Over/Under is 44.5 total points for the game.
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49ers vs. Rams Prediction
The winning team model predicts the 49ers will win this game with 70.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Based on recent against-the-spread trends, the model predicts the Rams will cover the spread with 67.0% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for 49ers players this playoff game, looking at profitable historical betting trends:
Best 49ers Player Prop Bets Today
- Christian McCaffrey has hit the Rushing Yards Over in 9 of his last 10 games (+7.85 Units / 67% ROI)
- George Kittle has hit the Longest Reception Over in 10 of his last 12 games (+7.60 Units / 54% ROI)
- Christian McCaffrey has hit the Longest Rush Over in 9 of his last 11 games (+6.75 Units / 53% ROI)
- Kyle Juszczyk has hit the Receiving Yards Over in his last 6 games (+6.00 Units / 89% ROI)
- Christian McCaffrey has hit the Carries Under in 10 of his last 13 games (+6.00 Units / 34% ROI)
And here are some top NFL player prop bets for Rams players for this matchup, looking at profitable historical betting trends:
Best Rams Player Prop Best Bets Today
- Demarcus Robinson has hit the Receiving Yards Over in his last 6 games (+6.00 Units / 86% ROI)
- Kyren Williams has hit the Carries Over in 9 of his last 12 games (+6.00 Units / 46% ROI)
- Tyler Higbee has hit the Receiving Yards Over in his last 5 games (+5.00 Units / 89% ROI)
- Colby Parkinson has hit the Receiving Yards Over in his last 5 games at home (+5.00 Units / 85% ROI)
- Kyren Williams has hit the Rushing Yards Over in his last 5 games at home (+5.00 Units / 83% ROI)
Receiving Props: Total Receiving Yards for Rams vs 49ers
| Player Name | Over | Under |
|---|---|---|
| 34.5 -125 | 34.5 -105 | |
| Brandon Aiyuk (SF) | 61.5 -115 | 61.5 -115 |
| George Kittle (SF) | 49.5 -110 | 49.5 -120 |
Rushing Props: Total Rushing Yards for Rams vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Brock Purdy (SF) | 8.5 -115 | 8.5 -115 |
| Kyren Williams (LAR) | 64.5 -115 | 64.5 -115 |
49ers Best Bets:
- The San Francisco 49ers have hit the 1H Game Total Over in 15 of their last 22 games (+7.25 Units / 30% ROI)
- The San Francisco 49ers have hit the 4Q Moneyline in 14 of their last 19 games (+6.15 Units / 17% ROI)
- The San Francisco 49ers have covered the 4Q Spread in 13 of their last 19 games (+5.85 Units / 27% ROI)
- The San Francisco 49ers have hit the 1H Moneyline in 16 of their last 22 games (+4.50 Units / 7% ROI)
- The San Francisco 49ers have covered the 1Q Spread in 7 of their last 10 away games (+4.15 Units / 37% ROI)
Rams Best Bets:
- The Los Angeles Rams have covered the 1Q Spread in 13 of their last 20 games (+5.55 Units / 23% ROI)
- The Los Angeles Rams have hit the Moneyline in 6 of their last 8 games at home (+4.35 Units / 28% ROI)
- The Los Angeles Rams have hit the 2Q Moneyline in 4 of their last 5 games at home (+4.00 Units / 52% ROI)
- The Los Angeles Rams have hit the 3Q Game Total Over in 11 of their last 17 games (+4.00 Units / 20% ROI)
- The Los Angeles Rams have covered the 3Q Spread in 5 of their last 7 games at home (+3.00 Units / 39% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers art 1-1 (-0.1 Units / -4.55% ROI).
- 49ers are 1-1 when betting on the Moneyline for -1.1 Units / -26.83% ROI
- 49ers are 1-1 when betting the Over for -0.1 Units / -4.55% ROI
- 49ers are 1-1 when betting the Under for -0.1 Units / ROI
Rams Against the Spread (ATS) Record
Against the spread this NFL season, the Rams are 0-2 (-2.2 Units / -100% ROI).
- Rams are 0-2 when betting on the Moneyline for -2.1 Units / -100% ROI
- Rams are 1-1 when betting the Over for -0.15 Units / -6.67% ROI
- Rams are 1-1 when betting the Under for -0.1 Units / -4.65% ROI
San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams
The 49ers are winless (0-3) when within 7 points at the two minute warning since the 2022 season — worst in NFL; League Avg: .500.
The 49ers were winless (0-3) when within 7 points at the two minute warning last season — worst in NFL; League Avg: .500.
The 49ers were winless (0-5) when scoring less than 22 points last season — T-worst in NFL; League Avg: .253.
The 49ers are undefeated (4-0) when committing less than 30 yards in penalties since the 2022 season — T-best in NFL; League Avg: .466.
Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers
The Rams were 8-3 (.727) when averaging more than 5 yards on first down plays last season — T-7th-best in NFL; League Avg: .579.
The Rams were 1-4 (.200) vs top 10 offenses last season — T-7th-worst in NFL; League Avg: .359.
The Rams were 6-1 (.857) when leading at the end of first quarter last season — 9th-best in NFL; League Avg: .737.
The Rams are 1-6 (.143) vs top 10 offenses since the 2022 season — T-6th-worst in NFL; League Avg: .358.
Additional Matchup Notes for San Francisco 49ers vs. Los Angeles Rams
The Rams have been successful on just 23.8% of plays they have ran against a light rush since the 2023 season — 3rd-worst in NFL. The 49ers have allowed their opponents to be successful on just 10.0% of plays with a light rush since the 2023 season — best in NFL.