Arizona Cardinals at Buffalo Bills odds, picks and predictions
Arizona Cardinals at Buffalo Bills odds, picks and predictions

The Arizona Cardinals'open the 2024 regular season on the road against the Buffalo Bills.'The game kicks off Sunday at 1 p.m. ET at Highmark Stadium (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Bills odds, and'make our expert NFL picks and predictions.

The Cardinals open the season with a healthy QB'Kyler Murray'and an improved defensive starting lineup. RB'James Conner'and TE'Trey McBride'are coming off career seasons. They are coming off a 4-win season and hope to take the next step, being competitive enough to perhaps make the playoffs.

The Bills remade their receiver room and their secondary. They have won the AFC East 4 straight years and hope to be a Super Bowl contender as QB Josh Allen'leads the way.

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Cardinals at Bills odds

  
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