We're coming off a week in which we went 5-0 with our NFL best bets, so you might not want to miss out on our favorite picks for Week 3. This column will be specifically focusing on the games that start after 4:00PM ET, so buckle up and let's get some winners in before the Sunday Night Football game between the San Francisco 49ers and Denver Broncos!
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Best Bets for the Late Games on Sunday, September 25, 2022
The Chargers were favored by nearly a touchdown when this line opened and now it's all the way down to just about a field goal. What that means is that Los Angeles star Justin Herbert will either miss this game or play at nowhere close to 100% health, as the young quarterback has a rib cartilage fracture that is really bothering him. Herbert is one of the best quarterbacks on the planet and he is the center of everything the Chargers do.
If Herbert isn't out there in this game, the Jaguars have a legitimate chance of going into L.A. and winning outright. This Jacksonville team is a lot better than it was a year ago, and last week's 24-0 win over the Indianapolis Colts served as something of a coming out party for Doug Pederson's team. Second-year quarterback Trevor Lawrence looks a lot better under center for the Jaguars, who also have an excellent 1-2 punch at running back in James Robinson and Travis Etienne. Jacksonville also has a pretty solid defense, headlined by a pass-rushing menace in Josh Allen.