San Francisco 49ers vs. Denver Broncos Prediction, Preview, and Odds – 9-25-2022
San Francisco 49ers vs. Denver Broncos Prediction, Preview, and Odds – 9-25-2022

This Sunday night the (1-1) San Francisco 49ers and the (1-1) Denver Broncos will match up in the third week of the 2022 NFL season. Kick-off will be at 8:20 PM EST inside Empower Field at Mile High. Both of these teams have had an interesting start to their season, as they are both (1-1) and dealing with a ton of injuries.

The San Francisco 49ers are coming into this one after taking down the Seattle Seahawks, 27-7. They did lose their starting quarterback Trey Lance for the season, as he suffered an ankle injury. The 49ers will now be starting Jimmy Garoppolo in this one.

The Denver Broncos picked up their first win of the season last week against the Houston Texans. They won 19-9 as they also lost some key players to injury. Jerry Jeudy is listed as questionable for this one, as he got banged up in week 2. They will need to get multiple players back if they want to have a shot on Sunday Night !

The 49ers are currently scoring 18.5 points per game and averaging 352 total yards of offense. This is the 19th most points scored per game and the 15th most yards. The San Francisco 49ers lost Trey Lance for the season last week, as he went down with an ankle injury. They will now be starting Jimmy Garoppolo at quarterback. Last week he entered the game and finished with 154 passing yards, 1 touchdown, and a 60.4 QB rating. He looked solid, but the 49ers will still be looking to lean on the run. According to TeamRankings.com, they are averaging 182.5 rushing yards per game, which is the fourth most in the league. They will continue to feed Jeff Wilson. He finished with 84 yards against the Seahawks, as he continued to pound the rock. San Francisco is also averaging 169.5 passing yards per game, as this is the second l east. They haven't relied on their passing game much this season, but now that Garoppolo is starting, I would expect to see the ball in the air more. I would also watch for Deebo Samuel, as he can get the job done on the ground or in the air. He is a main focal point in their offense. George Kittle is also listed as questionable, as the 49er's star tight end still hasn't played this season.

On defense, the 49ers have been great. They are currently allowing 13 points per game and 210 total yards. This is the third least amount of points given up per game and the least amount of yards. The Seahawks and the Bears struggled to move the ball against them. They were especially good against the run, as they are only allowing 67.5 rushing yards per game. Their front seven and linebackers have been rallying to the ball with some speed to begin the season. This is also the second least amount of rushing yards allowed per game. Now, the San Francisco secondary has been solid, as well. They are only allowing 142.5 passing yards per game, which is also the least in the league. Moving the ball against the 49ers has been a challenge this season. I would also watch for Nick Bosa, as he will be looking to put some pressure on Russel Wilson and the Broncos. He has already recorded three sacks this season.

  
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