Seeking an extension of their strong record in Buffalo, the Bills welcome the Cardinals for Week 1 of the 2024 season.'
Questions surround the Bills, the current favorites in the AFC East odds. Buffalo lost both Stefon Diggs and Gabe Davis this offseason, leaving unknowns about their offense.'
As for Arizona, they're projected to finish last in their division based on NFC West odds following a 4-13 campaign in 2023.'
Let's take a look at the NFL Betting Lines for the Week 1 game, along with my prediction.'
Bills vs. Cardinals Odds
- Buffalo Bills Moneyline: -275
- Arizona Cardinals Moneyline: +220
- Game Spread: Bills -6
- Game Over/Under: 48 Points