The San Francisco 49ers visit the'Tennessee Titans as both teams open the preseason. Kickoff from Nissan Stadium is set for 7 p.m. ET (NFL+). Below, we analyze BetMGM Sportsbook’s'lines around the 49ers vs. Titans odds, and'make our expert NFL picks and predictions.
San Francisco finished atop the NFC West last year with a 12-5 record en route to a Super Bowl appearance, where the Niners lost 25-22 in OT to the Kansas City Chiefs. The 49ers are in a standoff with WR Brandon Aiyuk, the team’s leading receiver last year, who is demanding a trade.
Tennessee ended last year with a 6-11 record, finishing in last place in the AFC South. The Titans drafted OT JC Latham'with the 7th overall pick in the draft. The Titans lost RB Derrick Henry'to the Baltimore Ravens in free agency.
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