Los Angeles Rams vs. Arizona Cardinals Prediction, Preview, and Odds – 9-25-2022
Los Angeles Rams vs. Arizona Cardinals Prediction, Preview, and Odds – 9-25-2022

Los Angeles Rams (1-1) vs. Arizona Cardinals (1-1)

Week 3 of the 2022 NFL season brings the NFC West showdown from State Farm Stadium in Glendale, Arizona, where the Cards host the reigning Super Bowl champions, so here’s the best Cardinals vs. Rams betting pick along with the latest odds update.   

It’s a rematch of the 2021 NFC wild-card round, and the Rams are listed as 3.5-point road favorites. The Cardinals are +155 moneyline underdogs with a total of 48.5 points.  

After getting humiliated by the Buffalo Bills in their season opener, the Los Angeles Rams beat the Atlanta Falcons 31-27 in Week 2. The reigning champs failed to cover a ten-point spread, surrendering 17 points in the fourth quarter while scoring just three in a return. Los Angeles had a 28-3 lead early in the third quarter, but the Falcons trailed by just six points with 4:57 left on the clock in the fourth. 

“There's a lot of different, very uncharacteristic things, but they happened. And we still found a way,” Rams head coach Sean McVay said. “We're not going to run away from some of the things that we didn't do well today. But we're also going to allow ourselves to appreciate being able to come away with a win.”