OddsJam's MLB experts take you through the betting odds, picks and predictions for this MLB matchup between the St. Louis Cardinals vs. the San Diego Padres on September 21, 2022 in San Diego.
Opening Lines via DraftKings Sportsbook
As a note, all odds in this preview of Cardinals vs. Padres are from opening lines. Odds can move at any time. Please check the table below for real-time betting odds!
The St. Louis Cardinals visit the San Diego Padres for this MLB matchup on September 21, 2022. First pitch for Wednesday's game is 9:40 p.m. ET / 6:40 p.m. PT in San Diego.
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