49ers vs Broncos Week 3 Game Info
2022 NFL Regular Season'Game
San Francisco 49ers'(1-1, 0-1 Away) vs.'Denver Broncos'(1-1, 1- 0 Home)
Date:'Sunday, Sept. 25, 2022
Time:'8:20 p.m. ET
Venue:'Empower Field at Mile High – Denver, CO
Coverage:'NBC
Week 3 of the 2022 NFL season includes a Sunday Night Football showdown between the San Francisco 49ers and Denver Broncos. After a disappointing loss to open the year, the 49ers bounced back with a 27-7 win against the Seattle Seahawks. Unfortunately, it wasn't all good news as San Francisco lost starting quarterback Trey Lance to a broken ankle for the rest of the season.
The Broncos also got their first win of the year by defeating the Houston Texans, 16-9, on Sunday. It was far from the most exciting game for Denver, however, wideout Courtland Sutto n did impress by pacing his team in targets (11), receptions (7) and receiving yards (122).
49ers vs Broncos Odds & Spread
Moneyline:'SF: (-116) | DEN: (-102)
Spread:'SF: -1 (-110) | DEN: +1 (-110)
Total:'45.5 -Over: (-110) | Under: (-110)
The 49ers enter this contest as the favorite on the moneyline and spread on FanDuel Sportsbook's NFL odds. This 8:20 p.m. ET game also features a total of 38.5, which is fairly average compared to the rest of the Week 3 slate.
49ers vs Broncos Prediction & Pick
Russell Wilson is no stranger to facing the 49ers, having played them 20 times as a member of the Seahawks. While he's won a whopping 16 of those matchups, things are a bit different now that he's playing with a Broncos offense playing below expectations, averaging 16.0 points per game (No. 26).
It isn't like the Broncos have even played any world-class defenses yet. Meanwhile, San Francisco just put up 27 points against the same Seattle defense that held Denver to 16 in Week 1. With the 49ers seemingly playing more confident with Jimmy Garoppolo under center as well, I could see San Francisco grabbing the road win here.
Final Score Prediction:'49ers: 28 | Broncos: 20
49ers vs Broncos Betting Trends
– San Francisco is 10-4 straight up in its last 14 games.
– Denver is 1-5 against the spread (ATS) in its last six games.
– The total has hit the under in six of San Francisco's last seven road games.
– The total has hit the under in four of Denver's last six games against San Francisco.
49ers vs Broncos Best Bet
As proven by the odds, this is a game that could go eith er way. While the Broncos were pegged as Super Bowl contenders, their offense hasn't come close to living up to its potential. I expect that the 49ers will be a more confident team with Garoppolo under center and with the spread situation being a pick'em, I'll take San Francisco as the 1-point favorite at -110 odds.