:format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/71384155/usa_today_19063153.0.jpg "Virginia vs. Syracuse odds: Opening odds, point spread, total for Week 4 college football matchup")
Syracuse has a chance to open the season 4-0 when the Orange host Virginia at the Carrier Dome on Friday, September 23. ESPN will handle the broadcast.
Virginia needed a last-second field goal from Brendan Farrell to beat Old Domionion 16-14, at home last Saturday, Quarterback Brennan Armstrong threw for 284 yards in his best game of the season.
Syracuse scored 22 fourth-quarter points in a wild finish to beat Purdue 32-29 last Saturday. Garrett Shrader connected with Orande Gadsden II with seven seconds left to push the Orange past the Boilermakers and remain undefeated.
Virginia vs. Syracuse opening odds
Spread: Syracuse -8.5
Total: 53.5