Rams vs 49ers Prediction, Odds & Best Prop Bets: NFL, Week 18
Rams vs 49ers Prediction, Odds & Best Prop Bets: NFL, Week 18

The Los Angeles Rams (9-6) visit Levi’s Stadium to take on the San Francisco 49ers (9-7) on Jan. 7. Kickoff is scheduled for 4:25pm EST in Santa Clara, CA.

The 49ers are betting favorites in this Week 18 matchup, with the spread sitting at -3 (-110).

The Rams vs. 49ers Over/Under is 42.5 total points for the game.

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Rams vs. 49ers Prediction

The winning team model predicts the 49ers will win this Week 18 game with 60.6% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 55.2% confidence.


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Best Rams Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for Rams players this Week 18 game, looking at profitable historical betting trends:

  • Matthew Stafford has hit the Passing Yards Under in 8 of his last 10 games (+5.50 Units / 45% ROI)
  • Ben Skowronek has hit the Receiving Yards Over in 8 of his last 12 games (+3.50 Units / 25% ROI)
  • Cooper Kupp has hit the Longest Reception Under in 7 of his last 10 games (+3.30 Units / 27% ROI)
  • Matthew Stafford has hit the Rushing Yards Over in 4 of his last 5 away games (+3.00 Units / 57% ROI)
  • Tyler Higbee has hit the Receiving Yards Under in 8 of his last 12 games (+3.00 Units / 19% ROI)

Best 49ers Player Prop Best Bets Today

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

  • George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
  • Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
  • Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
  • Christian McCaffrey has hit the Longest Rush Over in 12 of his last 17 games (+6.10 Units / 32% ROI)
  • Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)

  • The Los Angeles Rams have hit the 1Q Game Total Over in 7 of their last 10 away games (+3.95 Units / 36% ROI)
  • The Los Angeles Rams have hit the 3Q Game Total Over in 11 of their last 17 games (+3.80 Units / 19% ROI)
  • The Los Angeles Rams have scored first in 6 of their last 9 away games (+3.60 Units / 36% ROI)
  • The Los Angeles Rams have hit the 1H Moneyline in 5 of their last 10 away games (+2.90 Units / 25% ROI)
  • The Los Angeles Rams have hit the 2H Game Total Over in 6 of their last 9 away games (+2.45 Units / 24% ROI)

  • The San Francisco 49ers have covered the 2H Spread in 15 of their last 20 games (+9.65 Units / 44% ROI)
  • The San Francisco 49ers have hit the 4Q Moneyline in 15 of their last 20 games (+7.40 Units / 19% ROI)
  • The San Francisco 49ers have covered the 4Q Spread in 14 of their last 20 games (+6.55 Units / 29% ROI)
  • The San Francisco 49ers have hit the 2H Moneyline in 15 of their last 20 games (+5.65 Units / 12% ROI)
  • The San Francisco 49ers have scored first in 8 of their last 10 games at home (+3.65 Units / 18% ROI)

Rams Against the Spread (ATS) Record

Against the spread this NFL season, the Rams went 8-6 (+1.4 Units / 7.95% ROI).

  • Rams are 9-7 when betting on the Moneyline for +2.1 Units / 8.08% ROI
  • Rams are 8-8 when betting the Over for -0.8 Units / -4.55% ROI
  • Rams are 8-8 when betting the Under for -0.8 Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers went 9-6 (+2.5 Units / 14.33% ROI).

  • 49ers are 12-4 when betting on the Moneyline for -0.65 Units / -0.86% ROI
  • 49ers are 8-7 when betting the Over for +0.3 Units / 1.7% ROI
  • 49ers are 7-8 when betting the Under for -1.8 Units / -10.23% ROI

Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers

The Rams are winless (0-6) when playing in cold weather since the 2022 season — worst in NFL; League Avg: .497.

The Rams are winless (0-3) vs top 10 pass offenses this season — T-worst in NFL; League Avg: .400.

The Rams are winless (0-6) vs top 10 run defenses since the 2022 season — worst in NFL; League Avg: .441.

The Rams were 1-7 (.125) when within 7 points entering the 4th quarter in the 2022 season — worst in NFL; League Avg: .497.

San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams

The 49ers are winless (0-4) when scoring less than 22 points this season — T-worst in NFL; League Avg: .246.

The 49ers are 5-1 (.833) when playing in cold weather since the 2022 season — best in NFL; League Avg: .497.

The 49ers are 10-2 (.833) after a home win since the 2022 season — best in NFL; League Avg: .482.

The 49ers are 3-1 (.750) vs top 10 pass offenses this season — T-3rd-best in NFL; League Avg: .400.

Additional Matchup Notes for Los Angeles Rams vs. San Francisco 49ers

  
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