The Los Angeles Chargers and Buffalo Bills will lock horns in Week 16 of the NFL season at SoFi Stadium on Saturday, with kickoff at 8:00PM ET.
Dimers.com's full betting preview for this week's Bills vs. Chargers matchup includes the latest betting odds, as well as our predictions and picks for the game.
Bills vs. Chargers Prediction: Who Will Win, Cover the Spread
We have used advanced machine learning and statistical analysis to simulate the outcome of Saturday's NFL matchup between the Bills and Chargers 10,000 times, in keeping with our coverage of NFL predictions.
Our famous predictive analytics model gives the Bills an 82% chance of defeating the Chargers in Week 16 of the NFL season, and our predicted final score has the Bills winning 25-16.
According to our model, the Chargers (+12) have a 58% chance of covering the spread, while the Over/Under total of 42.5 points has a 54% chance of going under.
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