The San Francisco 49ers (10-3) and Arizona Cardinals (3-10) meet Sunday at State Farm Stadium. Kickoff is set for 4:05 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s'lines around the 49ers vs. Cardinals odds, and'make our expert NFL picks and predictions.
The 49ers have won 5 straight games and are currently the No. 1 seed in the NFC. They beat the Seattle Seahawks 28-16 in Week 14 but did not cover the 16.5-point spread as home favorites.
The Cardinals had their bye in Week 14. Their last game was a 24-10 road win over the Pittsburgh Steelers in Week 13 as 6-point underdogs.
The 49ers won the Week 4 meeting 35-16 in Santa Clara.