:format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/71353571/1243122409.0.jpg "Penn State vs. Auburn odds: Opening odds, point spread, total for Week 3 college football matchup")
The No. 22 Penn State Nittany Lions head south to face the Auburn Tigers at Jordan Hare Stadium on Saturday, Sept. 17. Kickoff is set for 3:30 p.m. ET and will air on CBS.
Penn State's biggest challenge so far has been Purdue, and even an unranked Auburn is going to be a tough obstacle, particularly at home. The two teams met last year in a thriller for the first game of the home-and-home series in Happy Valley that saw the Nittany Lions emerge victorious, 28-20.
Auburn's win over San Jose State was a little too close for comfort this weekend, and Penn State will be the first Power 5 opponent they face this season. Bryan Harsin is looking to improve on his 6-7 record from his inaugural season as the Tigers' head coach.
Penn State vs. Auburn opening odds
Spread: Penn State -3
Total: 49