The Florida State Seminoles are looking to improve to 3-0 with a road win over a Louisville Cardinals team that is coming off of a big victory over the UCF Knights last week. These two are all set for a Friday September 16, 2022 clash at Papa John's Cardinal Stadium in Louisville, Kentucky.
Will the Seminoles continue their hot start to the year? You'll just have to keep reading our Florida State vs. Louisville betting preview to find out.
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For the most up to date CFB computer picks, check out our interactive predictions for Florida State vs. Louisville. It's constantly updating based on hundreds of different data points.