The annual primetime matchup on the three-game Thanksgiving holiday slate in the NFL rotates every year — the game has no set host, as opposed to the Lions and Cowboys always getting the first two games. This year, the primetime matchup (8:20 p.m. ET kickoff on NBC) is a big game from the NFC West as the San Francisco 49ers (7-3) visit the Seattle Seahawks (6-2)'in the first Thanksgiving game for both since they faced off in 2014. The Niners are -3.5 on the SportsLine consensus.& #39;
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