NFL Week 1 Same Game Parlays Odds, Picks & Predictions (2022)
NFL Week 1 Same Game Parlays Odds, Picks & Predictions (2022)

Finally, Week 1 of the NFL season is here. And betting parlays are one of the most exciting ways to get involved in the action. Each week, I’ll go through each game and give you my favorite same-game parlay picks, as well as my favorite parlay involving sides and totals.

Let’s roll right into my Week 1 parlay picks.

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  • Leg 1:'Under 40.5 in 49ers-Bears
  • Leg 2:'Houston Texans +7.5
  • Leg 3:'Pittsburgh Steelers +6.5

Odds: +530 ($100 to win $530)

The 49ers could be without George Kittle, making matters even harder for Trey Lance. Chicago has done a terrible job of surrounding Justin Fields with talent and protection. Plus, rain and high winds are expected. The Colts have lost their season opener every year under Frank Reich, and Week 1 divisional dogs are highly profitable. Pittsburgh’s offense has question marks, but the defense remains elite. Plus, Mike Tomlin is an excellent dog to back, as he’s 32-22-1 as a road underdog since 2007.

  • Leg 1:'Under 40.5
  • Leg 2:'Elijah Mitchell over 64.5 rushing yards
  • Leg 3:'Darnell Mooney over 4 receptions

  
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