The San Francisco 49ers (5-3) and Jacksonville Jaguars (6-2) meet Sunday at EverBank Stadium. Kickoff is set for 1 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Jaguars odds, and'make our expert NFL picks and predictions.
The 49ers failed to cover the spread as 4.5-point home favorites in a 31-17 loss Oct. 29 to the Cincinnati Bengals as the Over (44) hit. San Francisco, which had a bye in Week 9, has lost 3 straight, but will be getting WR Deebo Samuel'(shoulder) back after he missed most of the last 3 games.
Before their bye last week, the Jaguars covered as 2.5-point favorites in a 20-10 win at the Pittsburgh Steelers on Oct. 29 as the Under (41) cashed. Jacksonville has won and covered in 5 straight.
These teams have played each other once since Jaguars QB Trevor Lawrence'was drafted in 2021. The 49ers covered as 6.5-point road favorites in that meeting with a 30-10 victory as the Under (45) hit in 2021.