The San Francisco 49ers visit EverBank Stadium to take on the Jacksonville Jaguars on Nov. 12. Kickoff is scheduled for 1:00pm EST in Jacksonville.
The 49ers are betting favorites in this Week 10 matchup, with the spread sitting at -3 (-110).
The 49ers vs. Jaguars Over/Under is 45 total points for the game.
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49ers vs. Jaguars Prediction
Based on recent trends, the winning team model predicts the 49ers will win this Week 10 game with 55.3% confidence.
Based on recent against-the-spread trends, the model predicts the Jaguars will cover the spread with 58.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Jaguars, plus offensive & defensive matchups, recent games and key player performances this season.
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Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players this Week 10 game, looking at profitable historical betting trends:
- George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
- Christian McCaffrey has hit the Longest Rush Over in his last 7 away games (+7.00 Units / 89% ROI)
- Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
- Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)
Best Jaguars Player Prop Best Bets Today
And here are some top NFL player prop bets for Jaguars players for this matchup, looking at profitable historical betting trends:
- Travis Etienne has hit the Receptions Under in his last 7 games at home (+7.00 Units / 58% ROI)
- Christian Kirk has hit the Receptions Over in 12 of his last 18 games (+6.40 Units / 30% ROI)
- Trevor Lawrence has hit the Completions Over in 13 of his last 19 games (+6.35 Units / 30% ROI)
- Evan Engram has hit the Receptions Over in 9 of his last 14 games (+5.70 Units / 34% ROI)
- Travis Etienne has hit the Longest Rush Over in 11 of his last 16 games (+5.25 Units / 28% ROI)
Receiving Props: Total Receiving Yards for Jaguars vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Travis Etienne | 22.5 -120 | 22.5 -115 |
| Evan Engram | 47.5 -120 | 47.5 -110 |
| Christian Mccaffrey | 31.5 -115 | 31.5 -115 |
| Christian Kirk | 53.5 -115 | 53.5 -115 |
| Brandon Aiyuk | 62.5 -120 | 62.5 -115 |
Rushing Props: Total Rushing Yards for Jaguars vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Travis Etienne | 64.5 -115 | 64.5 -115 |
| Christian Mccaffrey | 66.5 -115 | 66.5 -115 |
| Trevor Lawrence | 16.5 -115 | 16.5 -115 |
49ers Best Bets:
- The San Francisco 49ers have hit the 4Q Moneyline in 14 of their last 20 games (+9.85 Units / 27% ROI)
- The San Francisco 49ers have covered the 2H Spread in 14 of their last 20 games (+8.75 Units / 40% ROI)
- The San Francisco 49ers have hit the 2H Moneyline in 15 of their last 20 games (+8.50 Units / 20% ROI)
- The San Francisco 49ers have hit the 2Q Game Total Over in 14 of their last 20 games (+7.10 Units / 32% ROI)
- The San Francisco 49ers have covered the 4Q Spread in 13 of their last 20 games (+5.00 Units / 22% ROI)
Jaguars Best Bets:
- The Jacksonville Jaguars have hit the Moneyline in 16 of their last 21 games (+11.85 Units / 37% ROI)
- The Jacksonville Jaguars have covered the Spread in 16 of their last 21 games (+10.55 Units / 46% ROI)
- The Jacksonville Jaguars have scored last in 13 of their last 18 games (+7.80 Units / 36% ROI)
- The Jacksonville Jaguars have covered the 4Q Spread in 13 of their last 18 games (+6.85 Units / 31% ROI)
- The Jacksonville Jaguars have hit the 2H Moneyline in 11 of their last 18 games (+6.75 Units / 29% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers went 4-3 (+0.8 Units / 9.25% ROI).
- 49ers are 5-3 when betting on the Moneyline for -4.75 Units / -14.94% ROI
- 49ers are 4-3 when betting the Over for +0.7 Units / 7.95% ROI
- 49ers are 3-4 when betting the Under for -1.4 Units / ROI
Jaguars Against the Spread (ATS) Record
Against the spread this NFL season, the Jaguars went 6-2 (+3.85 Units / 44% ROI).
- Jaguars are 6-2 when betting on the Moneyline for +2.65 Units / 19.34% ROI
- Jaguars are 4-4 when betting the Over for -0.4 Units / -4.55% ROI
- Jaguars are 4-4 when betting the Under for -0.4 Units / -4.55% ROI
San Francisco 49ers: Keys to the Game vs. the Jacksonville Jaguars
The 49ers are 7-4 (.636) when passing for 250 or more yards since the 2022 season — eighth-best in NFL. The Jaguars have allowed 246.5 passing yards per game since the 2022 season — third-worst in NFL.
The 49ers are undefeated (5-0) when allowing less than 3 explosive runs this season — tied for best in NFL; League Avg: .570.
The 49ers are undefeated (22-0) when not throwing an interception since the 2021 season — best in NFL; League Avg: .642.
The 49ers are 13-4 (.765) when allowing less than 3 sacks since the 2022 season — fourth-best in NFL. The Jaguars have averaged just 2.0 sacks per game over that time span — tied for third-worst in NFL.
Jacksonville Jaguars: Keys to the Game vs. the San Francisco 49ers
The Jaguars are 1-5 (.167) after a loss as favorites since the 2021 season — 2nd-worst in NFL; League Avg: .647.
The Jaguars are winless (0-11) when having a TO margin of -2 or worse since the 2021 season — tied for worst in NFL; League Avg: .129.
The Jaguars are 5-1 (.833) when allowing less than 50% of third down conversion opportunities this season — tied for 2nd-best in NFL; League Avg: .574.
The Jaguars are 6-1 (.857) when forcing 1 or more turnovers this season — tied for 3rd-best in NFL; League Avg: .572.