The Week 1 NFL slate features plenty of excitement, including the matchup between the Buffalo Bills and the Los Angeles Rams.
If you’re looking for additional betting intel for Week 1 in the NFL, we have you covered with betting odds for all the important matchups.
Week 1 NFL Games: Betting Information
College football odds courtesy of Tipico Sportsbook. Odds updated Wednesday at 7:56 PM ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Thursday
Buffalo hit the field against Los Angeles at 8:20 PM on Thursday at SoFi Stadium in Inglewood, California.
- Favorite: Buffalo (-2.5)
- Total: 52
- Moneyline: Buffalo (-134) | Los Angeles (+112)
Click here for a full betting preview
Sunday
San Francisco will play Chicago at 1:00 PM on Sunday at Soldier Field in Chicago, Illinois.
- Favorite: San Francisco (-7)
- Total: 40.5
- Moneyline: San Francisco (-310) | Chicago (+246)