It's important to preface this by saying that all books have slightly different numbers and that it's sometimes a bit hit-or-miss in researching historic college football odds, but Michigan is potentially the biggest favorite it has ever been at a whopping -51.5 for Saturday's game at the Big House against Hawaii. UM will give J.J. McCarthy his first career start at quarterback.
According to the two databases that I have access to , the previous biggest spread for Michigan was at -45.5 against visiting UMass on Sept. 15, 2012. The Wolverines covered in a 63-13 rout. Again, this doesn't mean that UM was never at least -52 in the years before that, but there's nothing on record – I'm from Michigan and I definitely don't remember a 50-point number. Incidentally, since 2005, favorites of 50 or more points have gone 26-41-1 (39%) against the spread.
Hawaii had more roster turnover from last season to this than any team in the country, with several players transferring out because they couldn't stand former coach Todd Graham and a bunch more transferring in under new coach Timmy Chang, one of the most prolific passers in NCAA history during his days at Hawaii. The Rainbow Warriors might be the worst FBS program right now after losing by 53 and 32 points at home to Vanderbilt and Western Kentucky, respectively.
The biggest margin by which Hawaii has been a dog on record is +43.5 at USC on Sept. 1, 2012, and UH covered in a 49-10 loss. In fact, the Rainbow Warriors are 2-0 ATS in their past two as at least a 42-point dog.