Sheffield United will square off against Manchester United at 3 p.m. ET on Saturday at Bramall Lane. Sheffield United are 0-1-7 overall and 0-1-3 at home, while Manchester United are 4-0-4 overall and 1-2 on the road. The latest Manchester United vs. Sheffield United odds list Manchester United as the -250 favorite (risk $250 to win $100) on the 90-minute money line, with Sheffield United the +600 underdog. A draw is priced at +410, and the over/under is 2.5 goals.
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![Sheffield United vs. Manchester United odds: English Premier League picks, Oct. 21 prediction from proven soccer insider Sheffield United vs. Manchester United odds: English Premier League picks, Oct. 21 prediction from proven soccer insider](https://splnhub.cbsistatic.com/i/2023/10/20/2cb5d19f-7c84-402a-9183-54285381e4cc/marcus-rashford-getty.jpg)