The defending AFC South champion Tennessee Titans open the 2022 NFL season with a Week 1 home game against the New York Giants on Sunday afternoon in Nashville. The Giants went 4-13 and are in the midst of a reorganization that includes new head coach Brian Daboll. Tennessee won 12 games last season despite numerous injuries that included star running back Derrick Henry missing more than half the season.
Kickoff is set for 4:25 p.m. ET at Nissan Stadium. Tennessee is a 5.5-point favorite in the latest Giants vs. Titans odds from Caesars Sportsbook, and the Over/Under for total points scored is 43.5. Before you make any Titans vs. Giants picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.
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The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.