The No. 25 Louisville Cardinals (5-0) welcome the No. 11 Notre Dame Fighting Irish (5-1) to L&N Federal Credit Union Stadium Saturday. Kickoff is set for 7:30 p.m. ET (ABC). Below, we analyze BetMGM Sportsbook’s'lines around the Notre Dame vs. Louisville odds, and make our expert college football picks and predictions.
The Fighting Irish went to Duke, where College Gameday was, and beat the Blue Devils 21-14 in Week 5, covering as 4.5-point favorites. Notre Dame suffered its lone loss the week prior to the No. 3 Ohio State Buckeyes, covering as a 3.5-point home underdog. The Fighting Irish are 5-1 against the spread (ATS).
The Cardinals are 2-2-1 ATS and beat the NC State Wolfpack 13-10 on the road in Week 5, pushing as 3-point favorites. Louisville is 2-0 ATS at home this season. It is led by QB Jack Plummer, who has 11 touchdowns and 1,406 passing yards on the season.
Notre Dame is No. 11 and Louisville is No. 25 'in the US LBM Coaches Poll powered by USA TODAY Sports.