The No. 11 Notre Dame Fighting Irish (5-1) take on the No. 25 Louisville Cardinals (5-0) in Louisville on Saturday at 7:30 p.m. (ABC). Below, we analyze FanDuel Sportsbook’s lines around the Notre Dame'vs. Louisville odds, and make our expert college football picks and predictions.
Notre Dame is coming off a defensive struggle against Duke on Saturday. Entering the game as 4.5-point favorites, Notre Dame pulled out a last minute 21-14 win to cover.
Louisville had its toughest game to date last Friday scratching out a 13-10 road win as 3-point favorites against NC State. Notre Dame will be coach Jeff Brohm’s biggest test to keep the Cardinals undefeated.
Notre Dame is No. 11 and Louisville No. 25 in the US LBM Coaches Poll powered by USA TODAY Sports.