The defending Super Bowl champion Los Angeles Rams host the Buffalo Bills to kick off the 2022 NFL season. We're breaking down the betting with our Bills-Rams picks.
The Bills enter the season as the favorites to win the Super Bowl for the first time since the Jim Kelly era. Meanwhile, the Rams have the daunting task of trying to be the first team to repeat as Super Bowl champions since the New England Patriots did it in 2003 and 2004.
Here are our Bills-Rams NFL picks for Week 1 (odds via Caesars Sportsbook, PointsBet, DraftKi ngs Sportsbook; pick confidence based on a 1-to-5-star scale).
Bills vs. Rams Game Info
Date/Time: Thursday, Sept. 8, 8:20 p.m. ET
TV: NBC
Location: SoFi Stadium, Inglewood, CA
Weather: 94 degrees, 1% chance of precipitation, 7-mph SSW winds