The NFL season begins with the defending champion Los Angeles Rams playing as home underdogs against the Buffalo Bills for a little Thursday Night Football. This one will begin at 8:20PM ET and it'll be played at SoFi Stadium, where you'll surely see some of the biggest stars in Hollywood out there to pretend they like one of these two teams.
Find out whether we think Buffalo will handle its business against Los Angeles in our Bills vs. Rams betting preview below.
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For the most up to date NFL computer picks, check out our interactive predictions for Bills vs. Rams. It's constantly updating based on hundreds of different data points.