- Louisville and Syracuse jump right into their ACC schedules in college football's Week 1.
- Will the Cardinals use their strong run defense and overall better team to take down the Orange?
- Stuckey dives deep into this matchup between these two programs.
Louisville vs. Syracuse Odds
Saturday, Sept. 3 8 p.m. ET ACC Network
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
| -5.5 -110 | 55.5 -106o / -114u | -210 |
| Syracuse Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
| +5.5 -110 | 55.5 -106o / -114u | +172 |
Odds via'FanDuel.'Get up-to-the-minute'college football odds here.
There are no tune-ups for either one of these ACC programs that will play a conference game right out of the gates.
Since finishing 10-3 with a final top-15 national ranking in 2018, Syracuse has continued to trend downward. The Orange have finished under .500 in each of the past three seasons with a disappointing 11-24 overall record.
During that span, Louisville has dominated this series, winning all three meetings with ease. The Cardinals won each by at least three touchdowns, including two straight beatdowns by a combined score of 71-3.
Syracuse hopes a change of scenery will lead to better results. After making three straight trips to Kentucky, the Orange will finally get to host this series for the first time since a resounding victory back in 2018.