ACC foes match up when the Louisville Cardinals (0-0) and the Syracuse Orange (0-0) play on Saturday, September 3, 2022 at the JMA Wireless Dome.
The Cardinals went 6-7 last season and lost in the First Responder Bowl. They scored 31.6 points per game (41st in the nation) while allowing 27.3 (78th). The Orange went 5-7 in 2021 and failed to qualify for a bowl game. They gave up 26.3 points per game (to rank 65th in college football) while scoring 24.9 per game (92nd).
The Orange are 4.5-point underdogs in their matchup against the Cardinals (the game has an over/under of 56.5 points).
Check out: AFCA Coaches Poll powered by USA TODAY sports