OddsJam's NFL experts take you through the betting odds, picks and predictions for this matchup between the Seattle Seahawks and the San Francisco 49ers. This game is set to kick off on September 18, 2022. The San Francisco 49ers are at home for this game.
Seattle Seahawks vs. San Francisco 49ers Betting Odds
The Seattle Seahawks visit the San Francisco 49ers for this NFL matchup on September 18, 2022. Kickoff for Sunday's game is 4:05 p.m. ET / 1:05 p.m. PT.
The San Francisco 49ers are favored at -375 moneyline odds on FanDuel. The Seattle Seahawks are +300 underdogs on the moneyline in this matchup vs. the San Francisco 49ers and +7.5 on the point spread at -110 odds.