Penguins vs. Avalanche Odds, Picks, Predictions: Can Colorado Stay Hot at Home?

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The Colorado Avalanche have won six straight games and are set to host a struggling Pittsburgh Penguins team. Read on for our best Penguins vs. Avalanche picks based on the best NHL odds.

The Avalanche have been bitten by the injury bug this season, but they've worked through it. The Avs have won six straight games but may be without Cale Makar again Wednesday, and Evan Rodrigues has already been ruled out.

On the other hand, the Penguins' last dance might be cut short. Sidney Crosby & Co. have lost four straight games and scored a total of three goals in their last three contests.

Here is our best Penguins vs. Avalanche NHL pick (odds via BetMGM; pick confidence based on a 1-to-5-star scale).

Penguins vs. Avalanche pick

These are two teams headed in opposite directions. The Avalanche, even through all of their injuries, are gearing up for another Stanley Cup run, while the Penguins' playoff hopes continue to dwindle.

Goaltending has been one of Pittsburgh's main issues, and that could continue Wednesday. Tristan Jarry is likely to start in the first half of a back-to-back, and he's been poor as of late. He is 0-3 in his last four appearances, allowing 13 goals on 79 shots (.835 save percentage).

Colorado starter Alexander Georgiev has been great in his first season with the Avs. He boasts a 32-14-5 record with a 2.53 GAA and .920 SV%.

Home-ice advantage is extra important in the Mile High City. Colorado is 19-11-5 at home while Pittsburgh is a paltry 15-15-5 on the road.

Penguins vs. Avalanche best odds

DraftKings	FanDuel	BetMGM	Caesars	PointsBet
Avalanche ML	Avalanche ML	Avalanche ML	Avalanche ML	Avalanche ML
-165	-162	-160	-160	-160

The odds have stabilized a bit as of Wednesday morning with the Avalanche ranging from -160 to -165 at our top-rated sportsbooks.