OddsJam's NFL experts take you through the betting odds, picks and predictions for this NFL preseason matchup between the San Francisco 49ers and the Houston Texans. This game is set to kick off on August 25, 2022. The Houston Texans are at home for this game in Week 3 of the NFL preseason.
San Francisco 49ers vs. Houston Texans Betting Odds
The San Francisco 49ers visit the Houston Texans for this NFL matchup on August 25, 2022. Kickoff for Thursday's game is 8:00 p.m. ET / 5:00 p.m. PT.
The San Francisco 49ers are favored at -165 moneyline odds on DraftKings. The Houston Texans are +140 underdogs on the moneyline in this matchup vs. the San Francisco 49ers and +3 on the point spread at -110 odds.