The Green Bay Packers'and San Francisco 49ers meet in their preseason opener Friday. Kickoff from Levi’s Stadium for 8:30 p.m. ET (NFL Network). Below, we analyze Tipico Sportsbook’s lines around the Packers vs. 49ers odds, and make our best NFL picks, predictions and bets.
The Packers will have their starting offensive line in action Friday, although MVP QB Aaron Rodgers will not play. Backup QB Jordan Love is expected to draw the start and will likely play plenty.
The 49ers might potentially start QB Nate Sudfeld, with former Iowa State product QB Brock Purdy as the backup. If new starter QB Trey Lance does play, it likely will be a cameo, and the team is unlikely to use QB Jimmy Garoppolo and risk a potential injury that would crush his possible trade value. WR/RB Deebo Samuel is also unlikely to suit up.
Packers at 49ers odds
Odds provided by Tipico Sportsbook; access'USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 3:41 p.m. ET.
- Money line (ML): Packers +115 (bet $100 to win $115) | 49ers -140 (bet $140 to win $100)
- Against the spread (ATS): Packers +2.5 (+100) | 49ers -2.5 (-120)
- Over/Under (O/U): 33.5 (O: -103 | U: -117)