The preseason hasn’t been kind to either head coach featured in this matchup, both of whom took up their respective posts in 2019. Cardinals’ coach Kliff Kingsbury has a 2-4 preseason record with the team and Bengals’ Zac Taylor has had nearly identical luck at 2-5.
Both teams will be without key starters, meaning this game will ultimately come down to strategy and depth.
Here are our Cardinals-Bengals NFL picks for preseason Week 1 (odds via DraftKings Sportsbook, FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).