Washington Commanders vs San Francisco 49ers Prediction, 12/24/2022 NFL Picks, Best Bets & Odds Week 16
Washington Commanders vs San Francisco 49ers Prediction, 12/24/2022 NFL Picks, Best Bets & Odds Week 16 Levi's Stadium is the location where the San Francisco 49ers (10-4) will attempt to defeat the Washington Commanders (7-6-1) on Saturday. San Francisco opens this contest as 6.5-point favorites from Vegas oddsmakers. The over/under is 41. This game report has an NFL football pick, betting odds, and predictions for tonights key matchup.

  
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