The San Francisco 49ers would clinch the NFC West with a road win against the Seattle Seahawks this week. Read on for our 49ers-Seahawks NFL pick based on the top odds.
Niners quarterback Brock Purdy became the first-ever quarterback to beat Tom Brady in his first career start. The previous seven such quarterbacks who faced him in their first career starts lost by an average of 15.6 points, according to ESPN Stats & Info. San Francisco is amid its longest winning streak (six games) since 2019 and just won its eighth game by double-digits, the most of any team in the NFL.
Seattle trails San Francisco by two games entering this matchup and needs a win to keep its NFC West title hopes alive. The Seahawks lost 30-24 to the Panthers last week to fall to 0-4 against NFC South opponents.
Here is our best NFL pick for the Week 15 matchup between the 49ers and Seahawks (odds via FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).