The NFL kicks off in Mexico City Monday night and the 49ers are 8 points favorites. The biggest storyline is surrounding Kyler Murray being a game time decision. At the time of writing this article, there are only lines up for James Conner; no other Arizona skill players are listed. It's unfortunate, but there are still two angles that I really love that Murray's absence have little effect on. If Murray can't go, Colt McCoy will get the start. Based on the line being at 8 points, I am expecting McCoy to get the starting nod.
Deebo Samuel Over 50.5 Receiving Yards (-114)
Samuel has had a lot of success against this Cardinals team recently. Last season he averaged 60.5 yards receiving in two games against Arizona. He missed both games against the Cards in 2020, but in 2019 he exploded for 8 receptions in 134 yards. Now this Cardinals defensive is very different from 3 years ago, but they have some clear deficiencies that Samuel can exploit. The Cards rank 29th overall in DVOA for short passes; this is where 84% of Samuels receptions have come. In those short yardage situations, he is average 9.1 yards of YAC per reception. You could pivot to over 4.5 receptions at -135, but I feel comfortable with the yards at less juice. 1U from me. Play up to 53.5