The Los Angeles Chargers (5-3) take on the San Francisco 49ers (4-4) in Week 10 on the road in a prime-time matchup. Kickoff at Levis Stadium in Santa Clara is 8:20 p.m. ET (NBC). Below, we analyze Tipico Sportsbook’s lines around the Chargers vs. 49ers odds, and make our expert NFL picks and predictions.
The Chargers are coming off a 20-17 last-second win over the Atlanta Falcons and have won 4 of their last 5 games.
The 49ers are coming off their bye week. Two weeks ago, they fell behind 14-7 to the Los Angeles Rams, but came back to win 31-14 behind RB Christian McCaffrey, who rushed for a TD, had a TD reception and even threw a TD pass. That win snapped a 2-game losing streak.
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