49ers vs Vikings Prediction, Odds & Best Prop Bets: NFL, Week 2
49ers vs Vikings Prediction, Odds & Best Prop Bets: NFL, Week 2

The San Francisco 49ers (1-0-0) visit U.S. Bank Stadium to take on the Minnesota Vikings (1-0-0) on Sep. 15. Kickoff is scheduled for 1:00pm EDT in Minneapolis, MN.

The 49ers are betting favorites in this matchup, with the spread sitting at -6 (-110).

The 49ers vs. Vikings Over/Under is 45.5 total points for the game.

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49ers vs. Vikings Prediction

The winning team model predicts the 49ers will win this game with 67.5% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Based on recent against-the-spread trends, the model predicts the Vikings will cover the spread with 63.3% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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Best 49ers Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for 49ers players this playoff game, looking at profitable historical betting trends:

  • Christian McCaffrey has hit the Rushing Yards Over in 9 of his last 10 games (+7.85 Units / 67% ROI)
  • George Kittle has hit the Longest Reception Over in 10 of his last 12 games (+7.60 Units / 54% ROI)
  • Christian McCaffrey has hit the Longest Rush Over in 13 of his last 18 games (+7.10 Units / 34% ROI)
  • Christian McCaffrey has hit the Carries Under in 10 of his last 13 games (+6.00 Units / 34% ROI)
  • Kyle Juszczyk has hit the Receiving Yards Over in his last 5 games (+5.00 Units / 91% ROI)

Best Vikings Player Prop Best Bets Today

And here are some top NFL player prop bets for Vikings players for this matchup, looking at profitable historical betting trends:

  • T.J. Hockenson has hit the Longest Reception Over in 11 of his last 14 games (+7.95 Units / 49% ROI)
  • Josh Oliver has hit the Receiving Yards Over in his last 6 games (+6.05 Units / 87% ROI)
  • T.J. Hockenson has hit the Receiving Yards Over in 7 of his last 9 games (+4.95 Units / 48% ROI)
  • Aaron Jones has hit the Longest Reception Under in 6 of his last 7 games (+4.70 Units / 49% ROI)
  • Josh Oliver has hit the Receptions Over in his last 4 games (+4.45 Units / 72% ROI)

  • The San Francisco 49ers have hit the 3Q Game Total Over in 10 of their last 12 games (+7.60 Units / 52% ROI)
  • The San Francisco 49ers have covered the 1Q Spread in 9 of their last 11 away games (+7.15 Units / 54% ROI)
  • The San Francisco 49ers have hit the 4Q Moneyline in 15 of their last 20 games (+7.15 Units / 19% ROI)
  • The San Francisco 49ers have covered the 4Q Spread in 14 of their last 20 games (+6.95 Units / 31% ROI)
  • The San Francisco 49ers have hit the 1Q Game Total Over in 8 of their last 11 away games (+5.90 Units / 48% ROI)

  • The Minnesota Vikings have hit the 4Q Game Total Under in their last 8 games at home (+8.00 Units / 86% ROI)
  • The Minnesota Vikings have hit the 2Q Moneyline in 10 of their last 18 games (+6.85 Units / 32% ROI)
  • The Minnesota Vikings have hit the 2Q Game Total Over in 7 of their last 8 games at home (+6.00 Units / 65% ROI)
  • The Minnesota Vikings have hit the 3Q Game Total Over in 12 of their last 18 games (+5.70 Units / 28% ROI)
  • The Minnesota Vikings have covered the Spread in 11 of their last 21 games (+3.35 Units / 15% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL preseason, the 49ers went 1-0 (+1 Units / 90.91% ROI).

  • 49ers are 1-0 when betting on the Moneyline for +1 Units / 50% ROI
  • 49ers are 1-0 when betting the Over for +1 Units / 90.91% ROI
  • 49ers are 0-1 when betting the Under for -1.1 Units / ROI

Vikings Against the Spread (ATS) Record

Against the spread this NFL preseason, the Vikings went 1-0 (+1 Units / 90.91% ROI).

  • Vikings are 1-0 when betting on the Moneyline for +1 Units / 90.91% ROI
  • Vikings are 0-1 when betting the Over for -1.1 Units / -100% ROI
  • Vikings are 1-0 when betting the Under for +1 Units / 90.91% ROI

San Francisco 49ers: Keys to the Game vs. the Minnesota Vikings

The 49ers were winless (0-3) when within 7 points at the two minute warning last season — worst in NFL; League Avg: .500.

The 49ers were 9-4 (.692) when forcing 1 or more turnovers last season — T-7th-best in NFL. The Vikings turned the ball over 34 times last season — 2nd-most in NFL.

The 49ers are 12-5 (.706) when passing for 250 or more yards since the 2022 season — 6th-best in NFL. The Vikings have allowed 247.6 passing yards per game since the 2022 season — 2nd-worst in NFL.

The 49ers were winless (0-5) when scoring less than 22 points last season — T-worst in NFL; League Avg: .254.

Minnesota Vikings: Keys to the Game vs. the San Francisco 49ers

The Vikings were 2-8 (.200) when throwing at least 1 interception last season — T-8th-worst in NFL. The 49ers intercepted 20 passes last season — 2nd-most in NFL.

The Vikings were winless (0-4) in the last 4 weeks of the regular season — T-worst in NFL; League Avg: .500.

The Vikings were 1-8 (.111) when intercepting no passes last season — 3rd-worst in NFL; League Avg: .348.

The Vikings were 1-5 (.167) when the opposing team converts 55% or more of its red zone chances into touchdowns last season — T-2nd-worst in NFL; League Avg: .442.

Additional Matchup Notes for San Francisco 49ers vs. Minnesota Vikings

The Vikings had a third down conversion rate of 21.7% on 3rd and 10+ YTG last season — 5th-best in NFL. The 49ers defense allowed a third down conversion rate of 25.0% on 3rd and 10+ YTG last season — 2nd-worst in NFL.

  
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