49ers vs Seahawks Prediction, Odds & Best Prop Bets – NFL, Week 15, TNF

The San Francisco 49ers (9-4) visit Lumen Field to take on the Seattle Seahawks (7-6) on Dec. 15. Kickoff is scheduled for 8:15pm EST in Seattle for Thursday Night Football.

The 49ers are betting favorites in Week 15, with the spread sitting at -3.5 (-105).

The 49ers vs. Seahawks Over/Under is 43.5 total points for the game.

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49ers vs. Seahawks Prediction for Week 15

Based on recent trends, the winning team model predicts the 49ers will win this Week 15 game with 69.3% confidence.

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread this Week 15 with 60.0% confidence.

Both predictions factor in up-to-date player injuries for both the 49ers and Seahawks, plus offensive & defensive matchups, recent games and key player performances this season.


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Best 49ers Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 15, looking at profitable historical betting trends:

  • George Kittle has hit the Receptions Under in 13 of his last 18 games (+7.10 Units / 28% ROI)
  • Christian McCaffrey has hit the Receiving Yards Over in 8 of his last 10 games (+5.85 Units / 50% ROI)
  • George Kittle has hit the Receiving Yards Under in 12 of his last 18 games (+4.70 Units / 21% ROI)
  • Christian McCaffrey has hit the Carries Under in his last 4 games (+4.00 Units / 70% ROI)
  • Jimmy Garoppolo has hit the Completions Under in 10 of his last 15 games (+3.85 Units / 19% ROI)

Best Seahawks Player Prop Best Bets Today

And here are some top NFL player prop bets for Seahawks players for Week 15, looking at profitable historical betting trends:

  • Geno Smith has hit the TD Passes Over in 11 of his last 13 games (+9.90 Units / 64% ROI)
  • Rashaad Penny has hit the Receiving Yards Under in his last 6 games (+6.00 Units / 82% ROI)
  • Geno Smith has hit the Rushing Yards Over in 8 of his last 10 games (+5.90 Units / 54% ROI)
  • Geno Smith has hit the Passing Yards Over in his last 5 games (+5.15 Units / 94% ROI)
  • Geno Smith has hit the Completions Over in 9 of his last 13 games (+4.80 Units / 34% ROI)

Receiving Props: Total Receiving Yards for Seahawks vs 49ers

Player Name Over Under
Tyler Lockett 63.5 -120 63.5 -115
Will Dissly 15.5 -115 15.5 -115
George Kittle 40.5 -120 40.5 -110
Marquise Goodwin 23.5 -120 23.5 -110
Fant 29.5 -115 29.5 -115

Rushing Props: Total Rushing Yards for Seahawks vs 49ers

Player Name Over Under
Geno Smith 16.5 -110 16.5 -120
Christian Mccaffrey 75.5 -110 75.5 -120

  • The San Francisco 49ers have covered the 2Q Spread in 12 of their last 15 games (+8.95 Units / 53% ROI)
  • The San Francisco 49ers have covered the Spread in 13 of their last 18 games (+7.50 Units / 38% ROI)
  • The San Francisco 49ers have hit the Moneyline in 13 of their last 18 games (+7.50 Units / 18% ROI)
  • The San Francisco 49ers have hit the 2Q Moneyline in 11 of their last 14 games (+7.05 Units / 31% ROI)
  • The San Francisco 49ers have hit the 1H Game Total Over in 8 of their last 9 games (+6.95 Units / 71% ROI)

  • The Seattle Seahawks have hit the 1H Moneyline in 12 of their last 16 games (+9.85 Units / 43% ROI)
  • The Seattle Seahawks have hit the 4Q Game Total Over in 9 of their last 10 games (+7.80 Units / 67% ROI)
  • The Seattle Seahawks have hit the 2Q Game Total Over in 12 of their last 16 games (+7.40 Units / 41% ROI)
  • The Seattle Seahawks have hit the 1Q Game Total Over in 11 of their last 15 games (+6.65 Units / 40% ROI)
  • The Seattle Seahawks have hit the 2Q Moneyline in 11 of their last 17 games (+6.50 Units / 30% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers have gone 8-5 (+2.5 Units / 17.61% ROI).

  • 49ers are 9-4 when betting on the Moneyline for +2.25 Units / 7.11% ROI
  • 49ers are 6-7 when betting the Over for -1.7 Units / -11.89% ROI
  • 49ers are 7-6 when betting the Under for +0.4 Units / ROI

Seahawks Against the Spread (ATS) Record

Against the spread this NFL season, the Seahawks have gone 6-7 (-1.7 Units / -11.81% ROI).

  • Seahawks are 7-6 when betting on the Moneyline for +2.05 Units / 11.55% ROI
  • Seahawks are 8-5 when betting the Over for +2.45 Units / 17.07% ROI
  • Seahawks are 5-8 when betting the Under for -3.8 Units / -26.67% ROI

San Francisco 49ers: Keys to the Game vs. the Seattle Seahawks

The 49ers are undefeated (7-0) when the opposing team converts less than 55% of its red zone chances into touchdowns this season — tied for best in NFL; League Avg: .555.

The 49ers are winless (0-2) when allowing more than 3 explosive runs this season — tied for worst in NFL; League Avg: .393.

The 49ers are undefeated (11-0) vs bottom 10 run offenses since the 2021 season — best in NFL; League Avg: .547.

The 49ers are undefeated (13-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .543.

Seattle Seahawks: Keys to the Game vs. the San Francisco 49ers

The Seahawks are undefeated (4-0) when allowing less than 3 explosive runs this season — best in NFL; League Avg: .571.

The Seahawks are 3-10 (.231) when within 7 points at the two minute warning since the 2021 season — 3rd-worst in NFL; League Avg: .493.

  
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