49ers vs. Seahawks odds for NFL Thanksgiving have San Francisco as 7-point favorites on the spread with a game total over/under of 44. The 49ers actually opened at -5.5 on the line, but uncertainty surrounding the health of Seahawks quarterback Geno Smith has partially contributed to this line straddling the key number of seven.
San Francisco's offense has been a consistent machine under Brock Purdy when healthy, and the Seahawks have few answers to slow them down, even at home, which plays into my 49ers vs. Seahawks prediction for Thursday night.
First place is on the line in this nightcap of the NFL Thanksgiving tripleheader. San Francisco (7-3) has a one-game lead in the division following consecutive comfortable wins against the Jaguars and Buccaneers. Seattle (6-4) suffered a last-second loss to the Rams at an unfortunate time as it now enters the gauntlet portion of the schedule with two games against the 49ers, plus the Cowboys and the Eagles.
49ers vs Seahawks Odds
Thursday, Nov. 238:20 p.m. ETNBC
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
| -7-105 | 44-110o / -110u | -360 |
| Seahawks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
| +7-115 | 44-110o / -110u | +280 |
Odds via'bet365. Get up-to-the-minute'NFL odds here.
49ers'vs'Seahawks'Prediction
Pick: Over 43.5 (Bet to 44)Bet the Over Instantly With FanDuel QuickSlip!