49ers vs Saints Odds, Pick, Prediction: Bet San Francisco as Big Favorite

  • The 49ers are big home favorites in Week 12 against the Saints.
  • San Francisco is thriving on offense with Jimmy Garoppolo under center.
  • Cody Goggin previews the matchup and lays out his betting pick below.

49ers vs Saints Odds

Sunday, Nov. 27 4:25 p.m. ET FOX

49ers Odds
Spread Total Moneyline
-8.5 -105 43 -110o / -110u -390
Saints Odds
Spread Total Moneyline
+8.5 -115 43 -110o / -110u +310

Odds via'FanDuel.'Get up-to-the-minute'NFL odds here.

The San Francisco 49ers are among the hottest teams in the league. They are coming off of a big win on Monday Night Football where they destroyed their division rival, the Arizona Cardinals, in Mexico City.

The New Orleans Saints, on the other hand, are having one of their most disappointing seasons in years, but they were able to pick up a win last weekend against the Rams. This New Orleans offense has been prone to disappearing this year under Andy Dalton, especially against good defenses.

In this game, the battle in the trenches will determine whether the Saints are able to score enough to hang around.

  
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